Value of heart-type fatty acid binding protein in the clinical diagnosis of early acute myocardial infarction
10.3760/cma.i.issn.1671-7368.2012.04.020
- VernacularTitle:心脏型脂肪酸结合蛋白对急性心肌梗死早期诊断价值的研究
- Author:
Jian WANG
;
Qiumei CAO
;
Yan FU
- Publication Type:Journal Article
- Keywords:
Heart-type fatty acid binding protein;
Myocardial infarction
- From:
Chinese Journal of General Practitioners
2012;11(4):287-289
- CountryChina
- Language:Chinese
-
Abstract:
A total of 115 patients with acute chest pain under the suspicion of acute myocardial infarction (AMI) were selected.By the onset time of chest pain,they were divided into two periods of ＜3 h and 3 -6 h respectively. Heart-type fatty acid binding protein (H-FABP)and such traditional cardiac biochemical markers as cardiac troponin T (cTnT),creatine kinase isoenzyme (CK-MB) and myoglobin (MYO) were tested to compare the sensitivity and specificity in the early diagnosis of AMI.The sensitivity of H-FABP was significantly higher than those of cTnT,CK-MB and MYO (P =0.026,0.005,0.048 ) ; the specificity of H-FABP was lower than those of cTnT,CK-MB in the diagnosis of AMI ( P ＞ 0.05 ).The sensitivities of H-FABP were 81.6％ and 78.1％ in the ST-elevation myocardial infarction (STEMI) and nonST elevation myocardial infarction (NSTEMI) groups respectively ( P =0.095 ).Regardless of the onset of chest pain at ＜ 3 h or 3 -6 h,the combination of H-FABP and cTnT had a higher sensitivity than those of cTnT,CK-MB and MYO in the early diagnosis of AMI (P =0.005,0.028).In the early and rapid diagnosis of AMI patients,H-FABP has a high sensitivity and a poor specificity.And it has some reference value.
