Diagnosis and treatment of adrenocorticotropic hormone-independent macronodular adrenocortical hyperplasia
10.3760/cma.j.issn.1671-7368.2012.04.022
- VernacularTitle:促肾上腺皮质激素非依赖性肾上腺皮质大结节增生症12例临床分析
- Author:
Jiang LI
;
Liming LI
- Publication Type:Journal Article
- Keywords:
Adrenal cortex diseases;
Cushing syndrome
- From:
Chinese Journal of General Practitioners
2012;11(4):292-294
- CountryChina
- Language:Chinese
-
Abstract:
Twelve cases of adrenocorticotropic hormone-independent macronodular adrenocortical hyperplasia were retrospectively reviewed.All cases had physical signs and biochemical evidence of Cushing syndrome. Urinary free cortisone(UFC)levels were not suppressed by high dose and low dose dexanethasone suppression tests,and plasma adrenocorticotropic hormone levels were low in all patients.CT scan showed bilateral enlarged adrenal glands in all cases,and histopathologic examination confirmed bilateral adrenal macronodular hyperplasia. The follow-up revealed that 4 patients had a normal blood pressure 8y after bilateral adrenalectomy. In 8 cases the blood pressure was rebound 3y after single side adrenalectomy,6 of whom had medical treatment; 2 of whom had contralateral adrenalectomy and the blood pressure returned to normal afterwards.There was no Nelson syndrome in all cases.
