Studies of interleukin-28B gene polymorphisms in human immunodeficiency virus/hepatitis C virus infected Han patients in Hubei Province
10.3760/cma.j.issn.1000-6680.2012.03.008
- VernacularTitle:湖北省汉族人类免疫缺陷病毒感染人群白细胞介素28B的基因多态性
- Author:
Dongxiao SI
;
Yong XIONG
;
Xien GUI
;
Liping DENG
;
Yajun YAN
;
Rongrong YANG
- Publication Type:Journal Article
- Keywords:
HIV;
Hepatitis virus;
Superinfection;
Interleukins;
Polymorphism,genetic;
Genotype
- From:
Chinese Journal of Infectious Diseases
2012;30(3):162-164
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo understand the distribution of interleukin(IL)-28B gene polymorphisms in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected Han patients in Hubei Province.MethodsOne hundred Han patients with anti-HIV and anti-HCV double positive in Hubei Province were enrolled.HCV RNA level was detected by fluorescence quantitative polymerase chain reaction (PCR) and genotyping of IL-28B gene was pcrformed by sequencing.The data were analyzed by chi square test.ResultsThe proportion of IL-28B C/C genotype was 95.0 ％ in target population,arnong which 21.1％ (20/95) were HCV RNA negative.While there were no HCV RNA negative cases in C/T and T/T genotypes (0/5;x2 =1.043,P=0.588).ConclusionAmong HIV/HCV coinfccted Han patients in Hubei Province,the proportion of IL-28B C/C genotype is high.
