Changes of serum soluble apoptosis factors and their relations with cognition disorders in the patients with vascular dementia
10.3760/cma.j.issn.0254-9026.2012.03.008
- VernacularTitle:血管性痴呆患者血清可溶性凋亡因子的变化及与认知障碍的关系
- Author:
Ruobing QI
;
Binhua CHEN
;
Zhonglin TAN
;
Zhen YU
;
Ziming XU
;
Waner ZHU
;
Xueqian SU
- Publication Type:Journal Article
- Keywords:
Dementia,vascular;
Apoptosis;
Cognition disorders
- From:
Chinese Journal of Geriatrics
2012;31(3):205-207
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of serum soluble factor-related apoptosis (sFas) and soluble Fas ligand (sFasL) and their relations with cognition disorders in the patients with vascular dementia (VaD). Methods Serum concentrations of sFas and sFasl were detected by enzyme-linked immunosorbent assay (ELISA) and compared between 70 patients with VaD aged (72.5± 7.5)years and 50 healthy elderly people aged(72.5 ± 7.5)years.The VaD patient's cognitive functions were evaluated by activity of daily living scale (ADL),mini mental state examination (MMSE) and hachinski ischemia score (Hachinski). Results The serum levels of sFas and sFasL in VaD patients were (228.0±60.7)μg/L and (146.8±30.1)μg/L,and in the healthy elderly were (62.4±22.6)μg/L and (82.3 ± 18.7)μg/L,respectively.The serum levels of apoptosis factors in VaD patients were significantly higher than in the healthy controls (t=20.883,14.453,P＜0.01).sFas level was negatively correlated with age,the scores of ADL and Hachiuski while positively with the scores of MMSE (r=-0.956,-0.943,-0.950 and 0.904,all P＜0.01). sFasL level was negatively correlated with the scores of MMSE while positively with age,the scores of ADL and Hachinski (r=-0.899,0.963,0.948 and 0.939,a11 P＜0.01). Conclusions Apoptosis may be involved in the pathological change during VaD and the serum levels of sFas and sFasL might be related with cognition disorders.
