Progress of high mobility group box 1 protein and sepsis
10.3760/cma.j.issn.1673-4408.2012.02.019
- VernacularTitle:高迁移率族蛋白B1与脓毒症的关系研究进展
- Author:
Dan WU
- Publication Type:Journal Article
- Keywords:
Sepsis;
High mobility group box 1 protein;
Cytokine
- From:
International Journal of Pediatrics
2012;39(2):170-173
- CountryChina
- Language:Chinese
-
Abstract:
High mobility groupbox 1 (HMGB1),a highly conserved protein previously known as a DNA-binding protein involved in maintenance of nucleosome structure and regulation of gene transcription,was recently found to act as a potent proinflammatory cytokine during infection responses.Levels of HMGB1 increase in serum and tissues during infection,especially in sepsis.A growing number of studies have demonstrated that HMGB1 is a cytokine that can mediate inflammation and is a potential therapeutic target in experimental models of sepsis.In this article,we will describe the biological function of HMGB 1 and HMGB 1 inhibitors for a potential role of inflammatory disease treatment.
