A clinical study of trazodone replacement treatment on benzodiazepine drugs dependence in senile patient
10.3760/cma.j.issn.1674-6554.2012.03.020
- VernacularTitle:曲唑酮治疗老年苯二氮卓类药物依赖患者临床观察
- Author:
Liqun XIAO
;
Peng LIAN
;
Wangxin ZHANG
;
Tian LIANG
;
Ruilan ZHOU
- Publication Type:Journal Article
- Keywords:
Trazodone;
Senile patient;
Benzodiazepine drugs dependence;
Cognitive function
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(3):253-254
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of trazodone replacement treatment on benzodiazepine drugs dependence and effect of cognitive function on senile patients.Methods 51 senile patients with benzodiazepine drugs dependence were assigned with dosage tacho-decrement and replaced by trazodone.The patients were discontinuanced taking benzodiazepine in 14 days and taken at a draught of trazodone before retiring about 6 months.Clinical effect and side effects were assessed with the Pittsburgh sleep quality index (PSQJ) and treatment emergent symptom scale(TESS) before and after treatment.Cognitive function was evaluated with Wechsler intelligence scale for adult-Chinese revised (WAIS-RC) and Wechsler mermory scale for adult-Chinese revised ( WMS-RC ) once before and after treatment.Results The scores total PSQJ( ( 13.17 ± 3.70),( 11.05 ± 3.48 ) ),the sleep quality( (2.36 ± 0.33 ),( 1.91 ± 0.29 ) ),daily function disorder,sleep disorder were significantly lower than before treatment while the other factor scores were not significantly changed.Trazodone wes effective without severe side effects and dependence.The study group showed significantly lower scores in learning,calculation,the signs of figure,wood puzzles,long-term memory,short-term memory,immediate memory,memory quotient in the assessment of cognitive function than after treatmemt (P ＜ 0.05 ).Conclusion Trazodone is an ideal medicine to senile insomnia.
