Effects of brain-derived neurotrophic factor and tvrosinekinase B in the disease of behavioral development in children
10.3760/cma.j.issn.1673-4408.2012.02.016
- VernacularTitle:脑源性神经营养因子及其受体在儿童发育行为疾病中的作用
- Author:
Jinlan CHEN
- Publication Type:Journal Article
- Keywords:
Brain-derived neurotrophic factor;
Tyrosine kinase receptor B;
Behavioral development
- From:
International Journal of Pediatrics
2012;39(2):158-161
- CountryChina
- Language:Chinese
-
Abstract:
Brain-derived neurotrophic factor(BDNF) is a key signaling molecule during the development of nervous system.When BDNF is binded tyrosine kinase receptor B ( Trk B ),it can lead to a variety of physiological effects.Although the mechanisms of their action remain unclear,studies have proved that they may be related to effects of nerve cell survival,growth,differentiation,repair after injury and apoptosis,etc.This review describes the affecting factors in the expression of BDNF and TrkB,the effects of BDNF and TrkB in the development of behavioral disorders and the relationship with early environment.
