Advancement of TREM-1
10.3760/cma.j.issn.1673-4408.2012.02.025
- VernacularTitle:髓样细胞触发受体-1研究进展
- Author:
Jianmei ZHAO
;
Yanlong BI
- Publication Type:Journal Article
- Keywords:
TREM-1;
Inflammation;
Signal transduction;
Marker
- From:
International Journal of Pediatrics
2012;39(2):191-195
- CountryChina
- Language:Chinese
-
Abstract:
Triggering receptor expressed on myeloid cells-1 ( TREM-1 ) is one of immunoglobulin superfamilies found recently.TREM-1 is a crucial molecule for the triggering and amplification of inflammatory response and promote the reduction of in anti-inflammatory factor by crosslinking reaction with its ligand after being activated,or increasing the level of transcription factor.This study shows that TREM-1 may be claimed as a marker of infection,and the blockade of TREM-1 may be a new approach to inflammatory diseases.This study summarizes its structure,signal transduction,expression,accommodation and clinical application.
