Update in growth hormone therapy of children
10.3760/cma.j.issn.1673-4408.2012.02.014
- VernacularTitle:生长激素在儿科应用进展
- Author:
Ying ZHANG
- Publication Type:Journal Article
- Keywords:
Recombinant human growth hormone;
Growth hormone deficiency;
Turner syndrome;
Idiopathic short stature
- From:
International Journal of Pediatrics
2012;39(2):151-154
- CountryChina
- Language:Chinese
-
Abstract:
Since recombinant human growth hormone (rhGH) was licensed for growth hormone deficiency(GHD) in 1985,it has been available in short stature associated with Turner syndrome (TS),being born small for gestational age,idiopathic short stature,chronic renal insufficiency in the last 20 years.The overall safety profile of rhGH continues to be favorable,but careful monitoring for the presence of certain conditions is important both during and after therapy.Reasonable indication,time of therapy and dosage are important to obtain the ideal result and save the expense.Besides,the efforts to improve rhGH therapy and increase compliance have also led to the investigation of extended-release rhGH and less invasive administration routes.Recent advances in the treatment of rhGH are reviewed in details.
