The impact of Chitosan Lecithin on the mild cognitive impairment patients' semantic understanding by event-related potential N400
10.3760/cma.j.issn.1674-6554.2012.03.004
- VernacularTitle:壳聚糖卵磷脂对轻度认知障碍患者语义理解事件相关电位N400的影响
- Author:
Haiying YANG
;
Qinghui MENG
;
Guichun XU
;
Xiuyan LI
;
Yu ZHANG
;
Yanchao SUN
- Publication Type:Journal Article
- Keywords:
Chitosan Lecithin;
Mild cognitive impairment;
Event-related potentials(ERP);
N400
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(3):203-205
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the impact of Chitosan Lecithin on the mild cognitive impairment(MCI) patients' semantic understanding by event-related potential N400.Methods 32 patients with MCI were screened from 500 elder people aged Court in Weifang by mini-mental state examination (MMSE) scale,and were divided into two groups:the observation group ( n=16) and the control group ( n=16) by the table of random numbers.The observation group were given Chitosan Lecithin while the control group were given an equal dose of placebo.The intervention time was 2 months.The subjects were asked to conduct semantic judgement by semantic violation experiment.Thirty-two channels electroencephalogram(EEG) was recorded by Neuroacan Nuamps Systerm and analyzed data.Results 1 ) Specific component N400 was found in both groups,which was distributed at the frontal,central and parietal regions.2 ) The observation group reaction time and correct rate were respectively (965.13 ± 178.07 ) ms and ( 92.56 ± 2.36 ) ％ ,while the control group were respectively ( 1126.13 ± 252.77 ) ms and (85.28 ± 5.73 )％,with significant difference(P ＜ 0.05 ).3 ) Compared with N400 in control group,N400 latency was shorter ( (425.28 ±47.26) ms vs (456.19 ± 37.75 ) ms,F=6.01,P＜0.05) and amplitude was higher ( (4.79 ±2.18)μV vs (3.59 ± 1.33) pV,F=5.96,P＜0.05).Conclusion Chitosan lecithin has the effect of N400 latency and amplitude,it may be helpful for the patients of MCI in semantic understanding.
