Meta-analysis of mycophenolate mofetil versus cyclophosphamide for diffuse proliferative lupus nephritis
10.3760/cma.j.issn.1673-4408.2012.02.030
- VernacularTitle:霉酚酸酯与间断性环磷酰胺静脉冲击疗法治疗弥漫增生型狼疮性肾炎的Meta分析
- Author:
Jing LI
;
Zhengkun XIA
;
Yuanfu GAO
;
Zhongmin FAN
;
Chunlin GAO
;
Xianguo REN
- Publication Type:Journal Article
- Keywords:
Mycophenolate mofetil;
Cyclophosphamide;
Diffuse proliferative lupus nephritis;
Meta-analysis
- From:
International Journal of Pediatrics
2012;39(2):208-211
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo estimate the application of mycophenolate mofetil (MMF) and cyclophosphamide(CTX) intravenous pulse therapy on diffuse proliferative lupus nephritis (DPLN).MethodPubMed,Medline,EMBASE and CNKI were searched from the establishment of the database.Meta-analysis of 14 comparative studies on MMF and CTX in treatment of DPLN was performed,taking the remission,the relapse,the death of MMF and CTX for DPLN as primary efficacy variable,mean while taking the herpes zoster as safety evaluating indicator.ResultsMMF was better than CTX in remission rate ( P ＜ 0.05 ).There was no difference between in incidence rate of the relapse,the death and the herpes zoste MMF and CTX for DPLN ( P ＞ 0.05 ).ConclusionMMF was better than CTX on the efficacy and safety in DPLN.
