Dynamic expression of Nogo-A receptor in the hippocampus following focal cerebral ischemia in rats

VernacularTitle:局灶性脑缺血大鼠海马Nogo-A受体的动态表达
Author: Zhihua YANG ; Yue CAO ; Jie XU
Publication Type:Journal Article
Keywords: Brain ischemia; Nogo protein; Receptors,cell surface; Hippocampus; Rats
From: International Journal of Cerebrovascular Diseases 2012;20(1):30-34
CountryChina
Language:Chinese
Abstract: Objective To investigate the dynamic expression of Nogo-A receptor (NgR) in the hippocampus following focal cerebral ischemia in rats.Methods The focal cerebral ischemia model was established by electrocoagulating the right middle cerebral artery in rats.The expression of NgR in the ischemic hippocampal CA1,CA2 and CA3 regions at different time points after cerebral ischemia were detected by immunohistochemical staining.Results The expressions of NgR were up-regulated in hippocampal CA1 and CA2 regions at the first day,in the CA3 region at the second day after cerebral ischemia; the expressions of NgR in the CA1 and CA2 regions at the fifth day was decreased to the lowest.The expressions of NgR was up-regulated again in the CA1 and CA2 regions at the 28th day.Conclusions The NgR expression in the hippocampus in ischemic side showed different change characteristics at different regions,however,the overall change trend showed a 2 peaks and a valley phenomenon,which indicated that NgR might have different functions at different time periods after cerebral ischemia.