Effects of physical exercises on cardiac function and plasma N-terminal pro-brain natriuretic peptide levels in hypertensive patients with diastolic cardiac disfunction
10.3760/cma.j.issn.1674-0815.2012.01.009
- VernacularTitle:运动锻炼对高血压伴单纯左室舒张功能不全患者心功能及血脑钠肽的影响
- Author:
Xiaolu LI
;
Hongyan DAI
;
Tao HE
;
Shuling YOU
;
Min XU
;
Mei XUE
;
Xiuhua ZHOU
;
Tao LI
;
Weidong CAI
;
Suhua YAN
;
Jigai LIU
;
Jian XIE
- Publication Type:Journal Article
- Keywords:
Hypertension;
Exercise;
Brain natriuretic peptide
- From:
Chinese Journal of Health Management
2012;06(1):32-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of physical exercises on cardiac function and plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in hypertensive patients combined with diastolic cardiac dysfunction.MethodsA total of 66 essential hypertension patients who had abnormal left ventricular relaxation and normal systolic function were assigned to the intervention group ( n =33 ; doing physical exercises once a day,5 days a week) or control group (n =33 ).All the patients received standard treatment.At 6 months,body weight,blood pressure,heart rate,NT-proBNP,and echocardiography were measured.ResultsAt 6 months,body weight [ (68 ± 7 ) kg vs (72 ± 8 ) kg ],systolic blood pressure [ (135.4 ±5.1) mm Hg (1 mm Hg =0.133 kPa) vs (141.9 ±5.2) mm Hg ],diastolic blood pressure [ (81.1 ±4.0) mm Hg vs (84.7 ±4.6) mm Hg],New York Heart Association class (1.4 ±0.3 vs 1.8 ±0.4),NT-proBNP level [ (526 ± 126 ) ng/L vs (741 ± 189 ) ng/L] were significantly decreased in the intervention group when compared with the control group ( all P ＜ 0.05 ) although left ventricular ejection fraction (LVEF) (62.9 ±6.7 vs 59.0 ±5.6) and E/A ratio ( 1.1 ±0.3 vs 0.9 ±0.3) were significantly increased ( both P ＜ 0.05).ConclusionPhysical exercises could play a role in reduced blood pressure and body weight and improved cardiac function in hypertensive patients with diastolic cardiac dysfunction.
