Risk analysis of upper gastrointestinal bleeding in elderly patients with aspirin and clopidogrel co-therapy
10.3760/cma.j.issn.1008-6706.2011.s2.003
- VernacularTitle:长期进行双联抗血小板治疗老年患者并发上消化道出血的危险因素分析
- Author:
Wang QIN
- Publication Type:Journal Article
- Keywords:
Gastrointestinal hemorrhage;
Aspirin;
Clopidogrel;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(z2):5-7
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the current occurrence of upper gastrointestinal bleeding in elderly patients in our hospital and its possible risk factors and treatment program.MethodsAn observational prospective analysis of medical records of 758 consecutive patients was performed.Clinical presentation,etiology and treatment were evaluated.The follow-up ended on the dates of a first occurrence of UGIB,stopping co-therapy,death or 6 months after admitted in the group.Results426 male and 332 female were admitted in the group,UGIB occurred in 48 patients.PPI,H2RA,gastric mucosa protectant plus PPI,gastric mucosa protectant plus H2RA and control were prescribed in 108,240,70,102,238 patients respectively.There were statistics difference in each group compared with control in bleeding rate.ConclusionThe occurrence of UGIB associated with A + C co-therapy in elderly was 6.3％.Co-prescription with PPI and gastric mucosa protectant was associated with a lower risk.
