Maternal and Perinatal Outcomes of Early- and Late-onset Preeclampsia.
- Author:
Eun Jeong JEONG
1
;
Young Nam KIM
;
Jong Hyuk KIM
;
Yu Kyung JO
;
Jung Mi BYUN
;
Dae Hoon JEONG
;
Kyung Bok LEE
;
Moon Su SUNG
;
Ki Tae KIM
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Inje University, Busan Paik Hospital, Busan, Korea. kiyn@freechal.com
- Publication Type:Original Article
- Keywords:
Preeclampsia;
Early onset;
Late onset;
clinical characteristics;
Neonatal outcome
- MeSH:
Apgar Score;
Birth Weight;
Blood Pressure;
Female;
Fetal Death;
Fetal Mortality;
Humans;
Hypertension;
Liver;
Maternal Age;
Parity;
Perinatal Mortality;
Pre-Eclampsia;
Pregnancy;
Pregnant Women;
Pulmonary Edema;
Retrospective Studies;
Uterus
- From:Korean Journal of Perinatology
2009;20(4):370-380
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Early-onset preeclampsia is thought to be associated with fetal mortality and maternal complications. We compared maternal clinical characteristics, complications, and perinatal outcome between early- and late-onset preeclampsia. METHODS: We analysed retrospectively 212 pregnant women with preeclampsia between 2004 and 2008 at a tertiary university hospital. We divided preeclamptic women as early-onset (n=58), with an onset before 32 weeks gestation, and late-onset (n=154), with an onset after 32 weeks gestation. We compared maternal characteristics, maternal complications, and neonatal outcomes between the two groups. RESULTS: There were no significant differences in maternal age, parity, BMI, previous history of preeclampsia, hypertension, and DM between early- and late-onset preeclampsia. Among the maternal complications, maternal blood pressure was higher in early-onset preeclampsia without any statistical significance, but the amount of 24 hours urine protein was significantly higher in early-onset preeclampsia than late-onset (P=0.003). There were significantly higher rate of visual disturbance, elevated liver enzyme, pulmonary edema and severe disease in early-onset preeclampsia (all P<0.05). Comparing neonatal outcome, there were higher rate of fetal death in uterus (FDIU) (P=0.0001), low Apgar score (P<0.0001), and perinatal death (P<0.0001) in early-onset preeclampsia. Fetal birth weight and onset of preeclampsia were significant covariate factors for perinatal mortality. CONCLUSION: Early-onset preeclampsia was related to poor perinatal and materanl outcomes, but there was no difference in maternal characteristics. Further studies are necessary for prediction, pathogenesis, and therapy of early-onset preeclampsia.
