The effect of high-dose mifepristone on the expression of HIF-1α and VEGF in the endometrial tissue
10.3760/cma.j.issn.1008-6706.2011.21.014
- VernacularTitle:大剂量米非司酮对子宫内膜腺组织中缺氧诱导因子-1α及血管上皮生长因子表达的影响
- Author:
Weiwei YAN
- Publication Type:Journal Article
- Keywords:
Mifepristone;
Endometrial neoplasms;
Hypoxia-inducible factor-1,alpha subunit;
Vascular endothelial growth factor A
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(21):2907-2908
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect of high-dose mifepristone on the expression of hypoxia-inducible factor 1,(HIF-1α) and vascular endothelial growth factor(VEGF) in the endometrial tissue and research the molecular mechanisms of mifepristone in treat ment of endometrial cancer.Methods30 patients with endometrial cancer who were treated were asked to oral mifepristone 100mg/d,the specimens from a biopsy or curettage were taken as the group before treatment,the specimens from surgery were as the group of after treatment.Another 10 cases of normal endometrium were selected as the control group.The expression of HIF-1α and VEGF were examined with immunohistochemistry.ResultsThe expression of HIF-1 α and VEGF(78.6 ± 3.5,92.4 ± 5.1 ) in endometrial cancer was significantly higher than normal endometrium( 192.3 ± 4.7,178.4 ± 3.3,P ＜ 0.01 ),large doses of mifepristone can significantly reduce the expression of HIF-1 α and VEGF in endometrial cancer issues ( 103.2 ± 4.1,118.3 ± 4.9,P ＜0.05).ConclusionOne of the molecular mechanisms of mifepristone inhibits the endometrial cancer was reduced HIF-1α and VEGF expression.
