The research of variation of T lymphocyte subsets and serum immunoglobulin for perioperative patients with thyroid cancer
10.3760/cma.j.issn.1008-6706.2011.21.008
- VernacularTitle:甲状腺癌患者围手术期外周血T淋巴细胞亚群及血清免疫球蛋白的变化
- Author:
Chunmei SHAO
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Intraoperative period;
T-lymphocyte subsets;
Immunoglobulins
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(21):2895-2896
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the variation of T lymphocyte subsets and serum immunoglobulin for perioperative patients with thyroid cancer.Methods74 cases in our hospital for radical surgical resection treatment and 131I treatment after surgery were chosen as the observation group.Take the level of T lymphocyte subsets and serum immunoglobulin for statistics.And then compared with 40 healthy people.ResultsThe observation group before surgery:NK cells:( 19.1 ± 4.6) ％,T cells:(68.2 ± 5.5 ) ％,the serum immunoglobulin before surgery was ( 13.4 ±1.4μg/L).It was significantly higher than the control group [ ( 15.2 ± 3.2 ),( 65.2 ± 5.2 ),( 4.3 ± 0.5 ) ] ; CD4+(32.1 ± 2.9),CD4+/CDs+ ( 1.1 ± 0.3 ).It was significantly lower than the control group ( 38.1 ± 3.9,4.3 ± 0.5 ).The difference was statistically significant ( t =24.5,17.8,33.6,14.5,22.5,all P ＜ 0.05 ).The observation group after surgery,1 month after 131I treatment,3 months after 131I treatment,NK cells ( 17.0 ± 3.3 ),( 16.9 ± 3.0),( 16.7 ±3.4) and serum immunoglobulin (5.1 ±0.6),(6.2 ± 1.0),(6.1 ± 1.0) were significantly higher than control group,the difference was statistically significant ( t =18.4,11.6,9.2,5.4,8.1,7.3,all P ＜ 0.05 ).ConclusionThe variation of T lymphocyte subsets and serum immunoglobulin for perioperative patients with thyroid cancer was regular,and could be used as one of the indicators to determine for tumor recurrence or metastasis.
