Influence of alcohol overtaking on the expression of Caspase-3 in the mouse seminiferous tubule

VernacularTitle:过量饮酒对鼠生精细胞caspase-3表达的影响
Author: Gan LU ; Xing HANG
Publication Type:Journal Article
Keywords: Testis; Apoptosis; Ethanol; Caspase; Mice
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(21):2913-2914
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the influence of overtaking of liquor on the expression of caspase-3 in the mouse seminiferous tubule.MethodsAdult mice were given liquor through the stomach.The dose was 4g/kg body weight per day for 5 continuous days.Hybridization in situ was performed for detecting the caspase-3 expression in the mouse seminiferous tubule.ResultsIn the control group,there were few Caspase-3 positive cells in the mouse seminiferous tubule.In the group of five days taking liquor,the caspase-3 positive cell count increased obviously.In the group of ten days taking liquor,the caspase-3 positive cell count was maximum.ConclusionAlcohol could induce the apoptosis of spermatogenic cell.