Comparing the blood gardenal concentration with clinical manifestations and the results of treating the acute gardenal-poisoned patients
- Author:
Nguyen Thi Du
- Publication Type:Journal Article
- Keywords:
gardenal
- MeSH:
Phenobarbital;
Phenobarbital/poisoning;
Blood;
Diagnosis;
Therapeutics
- From:Journal of Practical Medicine
2005;517(8):22-25
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
55 gardenal-poisoned patients were measured the drug’s blood levels to compare with their clinical manifestations and select appropriate treatment methods. The mean value was 36.87mg/l. The patients with the blood gardenal levels equal to or less than 60mg/l usually had first or second-stage coma, mild respiratory failure (if any), and fewer severe complications. This group of patients only required simple measures such as gastric lavage, the use of activated charcoal, enhanced diuresis and urine alkalization. Whereas the patients with the levels more than 60mg/l commonly suffered from third or fourth-degree coma, severe to life-threatening respiratory failure, hypotension and other severe complications. They not only needed simple curative methods but also mechanical ventilation and hemodialysis. the hemodialysis could reduce the blood gardenal concentration up to 665 for each intervention period. Owing to this extracorporeal technique for the removal of toxins, the duration of mechanical ventilation, enhanced diuresis, urine alkalization as well as the necessary amount of bicarbonate was decreased remarkably.
