A Review of Staphylococcus aureus Infections in Children with an Emphasis on Community-associated Methicillin-resistant S. aureus Infections.
- Author:
Young June CHOE
1
;
So Yeon LEE
;
Ji Yeon SUNG
;
Mi Ae YANG
;
Joon Ho LEE
;
Chi Eun OH
;
Jina LEE
;
Eun Hwa CHOI
;
Hoan Jong LEE
Author Information
1. Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. hoanlee@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Staphylococcus aureus;
Methicillin-resistant Staphylococcus aureus (MRSA);
Community-associated Staphylococcus aureus (CA-MRSA);
Childhood;
Korea
- MeSH:
Child;
Humans;
Infant;
Korea;
Methicillin Resistance;
Methicillin-Resistant Staphylococcus aureus;
Retrospective Studies;
Risk Factors;
Skin;
Soft Tissue Infections;
Staphylococcus;
Staphylococcus aureus;
Tertiary Healthcare
- From:Korean Journal of Pediatric Infectious Diseases
2009;16(2):150-161
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Staphylococcus aureus causes a variety of infections, ranging from benign skin infections to fatal invasive infections. Recently, methicillin-resistant S. aureus (MRSA) infections have emerged in patients who do not have established risk factors. This study was conducted to characterize S. aureus infections in children with an emphasis on community- associated MRSA infections at a tertiary care pediatric facility during a 3-year period. METHODS: Four hundred twenty-nine cases of S. aureus infections diagnosed at the Seoul National University Children's Hospital between January 2004 and December 2006 were retrospectively reviewed. The cases were classified as hospital- onset (HO) or community-onset (CO), healthcare-associated (HA), or community-associated (CA) infections. RESULTS: Among the 206 cases <1 year of age, 72%, 7%, and 21% were HO-HA, CO-HA, and CA infections, respectively, as compared to 48%, 28%, and 24% among the 223 cases >1 year of age. The proportion of CO-HA infections among HA infections (8.6% vs. 37.1%, P<0.001) and the proportion of HA infections among the CO infections (24.5% vs. 54.3%, P<0.001) were greater in older children than in infants. Overall, 57% of the isolates were methicillin-resistant. Twenty-nine (30%) of 96 CA strains were MRSA, and the most common site of CA-MRSA infection was the skin and soft tissues (26 cases). CONCLUSION: The methicillin resistance rate of S. aureus from CA infections was high and CA-MRSA was most often associated with skin and soft tissue infections.
