FHIT,p53 Expression and correlation in cervical cancer
10.3760/cma.j.issn.1008-6706.2011.21.004
- VernacularTitle:脆性组氨酸三联体基因及突变型p53基因在子宫颈癌组织中表达的关联性
- Author:
Huiyuan PENG
;
Ying ZHANG
;
Donghui MA
;
Yanling LI
- Publication Type:Journal Article
- Keywords:
Cervical intraepithelial neoplasia;
Genes p53;
Chromosome fragility;
Uterine cervical neoplasms
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(21):2887-2889
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the correlation and expression of fragile histidinetriad gene(FHIT) and p53 expressed in normal cervix,cervical intraepithelial neoplasia( CIN),cervial cancer( CC),and the significance of FHIT and p53 in the chnical diagnosis,treatment and prognosis of cervical cancer.MethodsIt was performed immunohistochemieal analysis of formalin fixed,paraffin-embedded 20 normal cervical(NC) biopsies,10 CIN1 samples、20CIN Ⅱ samples、20 CINⅢ samples and 70 cervical cancer samples to detect FHIT、p53expression.ResultsFHIT expressed 100％ (20/20) of normal cervical,60％ (6/10) of CIN Ⅰ,40％ (8/20) of CIN Ⅱ,25％ (5/20) of CINⅢ and 3％ (2/70) of cervical cancer;positive rate among the groups was different (P ＜ 0.05 ).p53 positive expressed in 0％ (0/20) of normal cervical,20％ (2/20) of CIN Ⅰ,35 ％ ( 7/20 ) of CIN Ⅱ,55％ ( 11/20 ) of CIN Ⅲ and 70％(49/70) of cervical cancer:positive rate among the groups was different (P ＜ 0.05 ).FHIT and p53 expression was negatively correlated with CIN and cervical cancer in the cervix ( P ＜ 0.05 ).ConclusionFHIT deletion and p53 overexpression was the early and common cases with the cervical cancer,which were negatively correlated in the pathogensis and development of cervical cancer:FHIT could screen the high risk of CIN,and give the basis of cervical cancer gene therepy.
