Expression and regulation of P-glycoprotein mediated by cellular microenvironment in cancer
10.3760/cma.j.issn.1673-422X.2012.02.004
- VernacularTitle:细胞微环境介导肿瘤P-糖蛋白的表达调控
- Author:
Fan HUANG
;
Yuan LI
;
Mingqing PENG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
P-glycoprotein;
Drug resistance;
Signal transduction
- From:
Journal of International Oncology
2012;39(2):92-95
- CountryChina
- Language:Chinese
-
Abstract:
Expression and regulation of the P-glycoprotein (P-gp) is associated with the development of multidrug resistance in cancer.Cancer cells are exposed in endogenous damages from its own micro-environments and inflicted stimulated damages.These harmful micro-environments could trigger cellular stress response and regulated the expression of P-gp through various activated signal transduction pathways.Researches of the cellular endogenous micro-environments and exogenous stimulation damages on the expression and regulation of P-gp would have important significance for exploring the multidrug resistance of cancer cell.
