Mechanisms of hypoxia triggering tumor development
10.3760/cma.j.issn.1673-422X.2012.02.009
- VernacularTitle:缺氧导致肿瘤发生的机制
- Author:
Baihong ZHANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Anoxia
- From:
Journal of International Oncology
2012;39(2):108-110
- CountryChina
- Language:Chinese
-
Abstract:
High-altitude hypoxia is closely associated with cancer initiation and progression.Hypoxia promotes tumor development through multiple mechanisms including modifying acidic microenvironment,triggering tumor angiogenesis,influencing vasculogenic mimicry,inducing epithelial-mesenchymal transition,remodeling of extracellular matrix,promoting immune escape and adaptive landscapes,maintaining cancer stem cells and inhibiting senescence.Targeting hypoxia may become a novel efficient strategy for cancer therapy.