DNA methylation and gastric cancer
10.3760/cma.j.issn.1673-422X.2012.02.018
- VernacularTitle:DNA甲基化与胃癌的相关性
- Author:
Jun LUO
;
Zhiqiang LING
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
DNA methylation;
Gene expression
- From:
Journal of International Oncology
2012;39(2):137-139
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal methylation of the tumor-related genes is frequently found in the development of gastric cancer.Cancer cells exhibit two opposing methylation abnormalities:genome-wide hypomethylation and certain tumor suppressor gene hypermethylation.Furthermore,it seems that the level of DNA methylation is closely associated with the prognosis of gastric cancer.Recently,a great deal of research has been conducted to reveal the corelation of DNA methylation and gastric cancer.
