The effect of phosphatidylinositol-3-kinase -protein kinase B signal pathway in colon cancer
10.3760/cma.j.issn.1673-422X.2012.02.020
- VernacularTitle:磷脂酰肌醇3激酶-蛋白激酶B信号通路在结肠癌中的作用
- Author:
Donghua MA
;
Liang ZHANG
;
Yaxu WANG
- Publication Type:Journal Article
- Keywords:
Signal transduction;
Molecular mechanisms of pharmacological action;
Colonic neoplasms;
PI3K-Akt
- From:
Journal of International Oncology
2012;39(2):143-145
- CountryChina
- Language:Chinese
-
Abstract:
The abnormal activation of phosphatidylinositol-3-kinase (PI3K)-proiein kinase B (Akt) pathway has already been confirmed to be closely related to the origin and development of various tumors.PI3KAkt pathway plays an important role in development of colon cancer,it can regulate cell survival,proliferation,anti-apoptosis,cell cycle progression,etc.Furthermore,inhibition of this pathway may play a potential roll in oncotherapy.
