Progress of stem cell surface marker CD133 in gastric cancer
10.3760/cma.j.issn.1673-4203.2012.01.018
- VernacularTitle:干细胞表面标志物CD133在胃癌中的研究进展
- Author:
Shoulian WANG
;
Ruiqi LU
;
Bojian JIANG
- Publication Type:Journal Article
- Keywords:
CD133;
Angiogenesis;
Gastric neoplasm
- From:
International Journal of Surgery
2012;39(1):56-59
- CountryChina
- Language:Chinese
-
Abstract:
The morbidity and mortality of gastric cancer stand in the first place among all kinds of malignant tumours in our country,the early diagnosis rate is still very low and the prognosis is unsatisfactory also.The expression of CD133 probably as a tumour stem cell marker is significantly higher in gastric cancer primary lesion than that in normal tissue and its higher expression corelates with the larger size of tumor,lymph node metastasis occurences and poorer prognosis.Meanwhile,the positive expression of CD133 may have some relationship with the angiogenesis,severer infiltration depth,worse differentiation degree and later TNM stage of gastric cancer.This paper aims at further recongnizing the specific expression of CD133 in gastric cancer primary lesion,both the relationship with initiating and clinical pathological features of gastric cancer,so as to bring a new research direction for early diagnosis and targeted therapy of stomach cancer.
