Regulatory T cell and tumor immunity
10.3760/cma.j.issn.1673-422X.2012.01.003
- VernacularTitle:调节性T细胞与肿瘤免疫
- Author:
Yuanli ZHANG
;
Quanlin GUAN
;
Bingdong ZHU
- Publication Type:Journal Article
- Keywords:
T-lymphocytes,regulatory;
Neoplasms;
Immunotherapy
- From:
Journal of International Oncology
2012;39(1):8-11
- CountryChina
- Language:Chinese
-
Abstract:
Regulatory T cells (Treg),a group of negative regulatory cells,have four subsets:CD4+Treg,CD8 + Treg,NKT Treg and DN Treg cells.They play an essential role in the inhibitive immune-regulation and might be the key factors of neoplasms immune escape.These mechanisms include inhibiting the effector cell function by inhibitory cytokines,killing effector cells by granzyme and perforin,competition and inhibiting IL-2,and affecting Treg differentiation and proliferation by regulating the function of CTLA-4,etc.Tumor immunotherapies targeting Treg and related immunosuppressive factors,such as remove Treg or controling the numbers and functions,enhances the immune response against tumors,which might offer a new method of tumor immunotherapy.
