Progress of nuclear transcription factor Sp1 regulating angiogensis of tumor

VernacularTitle:核转录因子Sp1调控肿瘤血管生成研究进展
Author: Bingxiang LOU ; Jun ZHANG
Publication Type:Journal Article
Keywords: Sp1 transcription factor; Neoplasms; Vascular endothelial growth factors
From: Journal of International Oncology 2012;39(1):18-21
CountryChina
Language:Chinese
Abstract: Sp1 is one of the nuclear transcription factors which are widely expressed in human body.It plays an important role in human growth and physiological activities,and is highly expressed in many kinds of tumors'tissue.Sp1 participates in regulating growth,invasion,angiogensis actions of tumor by regulating downstream gene(s) transcription.Some grow factors and tumor suppressor genes can regulate the expression of VEGF by Sp1,and then participate in angiogensis of tumor by two main mechanisms:kinases inducing Sp1 phosphorylation and the interact of Sp1 and other proteins.