Estrogen receptor coregulators and their roles in resistance to endocrine therapy of breast cancer
10.3760/cma.j.issn.1673-422X.2012.01.010
- VernacularTitle:雌激素受体共调节因子在乳腺癌内分泌治疗抵抗中的作用
- Author:
Juan YE
;
Hao ZHANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Receptors,estrogen;
Drug resistance,neoplasm
- From:
Journal of International Oncology
2012;39(1):31-34
- CountryChina
- Language:Chinese
-
Abstract:
The estrogen receptor (ER) coregulators regulate the transcriptional activities of ER,and then affect the transcription and translation of target genes mediated by ER.ER coregulators not only plays an important role in the initiation,progression and metastasis of breast cancer,but also involves in the response to endocrine therapy of breast cancer via the genomic and nongenomic function.
