Progress of EML4-ALK fusion gene non-small cell lung cancer inhibitor

VernacularTitle:EML4-ALK融合基因型非小细胞肺癌抑制剂究进展
Author: Qi ZHANG ; Feitianzhi ZENG ; Lei ZHANG
Publication Type:Journal Article
Keywords: Lung neoplasms; EML4-ALK fusion gene
From: Journal of International Oncology 2012;39(1):35-37
CountryChina
Language:Chinese
Abstract: EML4-ALK fusion gene is a new molecular type of non-small cell lung cancer,which is formed by inversion of two gene segments on chromosome 2.Up to now,9 subtypes have been found and all of them have deteriorated and carcinogenic abilities. The detection rate of this fusion gene is much higher in patients who have adenocarcinoma,never or seldom smoke and lack EGFR/KRAS mutation.This fusion gene codes ALK tyrosine kinase,that abnormally phosphorylates downstream products through signaling pathways,leading to canceration.Therefore,the specific inhibitors which target this fusion gene could inhibit its expression and have good treatment effect.At present,the relevent inhibitors which are undergoing clinical trials are PF02341066 and TAE684.