Treating effects of nourishing-kidnev herbs on rat models with glucocorticoid-induced osteoporosis
10.3760/cma.j.issn.1673-4246.2012.02.012
- VernacularTitle:补肾中药对糖皮质激素性骨质疏松模型大鼠的干预作用
- Author:
Hui ZHU
;
Hongxin ZHENG
;
Shuru LIN
;
Fang YANG
;
Jian WANG
;
Guozhe ZHANG
- Publication Type:Journal Article
- Keywords:
Glucocorticoid-induced osteoporosis,Dexamethasone;
Animal model;
Nourishing-kidney
- From:
International Journal of Traditional Chinese Medicine
2012;34(2):134-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of nourishing-kidney herbs on rat model with glucocorticoid-induced osteoporosis.Methods 60 Wistar rats male and female half and half were randomly divided into a normal group,a model group and a nourishing-kidney group.By intramuscular injection of dexamethasone (2.5 mg/kg) twice a week to replicate osteoporosis rat model.All groups were treated for 9 weeks.Detected the BMD of femur in vitro and determined the bone metabolism marker in serum by biochemical process.Results The BMD decreased obviously (0.109± 0.007)g/cm2 and the content of TRAP in serum increased evidently (9.96± 1.15) μg/ml in the model group.In the nourishing-kidney group,the BMD was up-regulated (0.116 ± 0.007)g/cm2,and TRAP down-regulated(5.76 ± 0.85)μg/ml.Conclusion Intramuscular injection of dexamethasone can induce GIO rat model,and nourishing-kidney herbs have the effect of anti-osteoporosis.
