Molecular targeted therapy of advanced gastric cancer
10.3760/cma.j.issn.1673-422X.2012.01.016
- VernacularTitle:进展期胃癌分子靶向治疗
- Author:
Runjie WANG
;
Xiaoyan SHI
;
Wei HUANG
;
Chaoying LIU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Molecular targeted therapy
- From:
Journal of International Oncology
2012;39(1):50-53
- CountryChina
- Language:Chinese
-
Abstract:
Efficacy of chemotherapy for advanced gastric cancer is unsatisfactory. Molecular targeted therapies have emerged as a novel approach to the treatment of advanced gastric cancer in recent years.These therapeutic strategies include targeting EGFR signal transduction pathway,anti-angiogenesis therapy,multi-target molecular targeted drugs. Targeted drugs such as trastuzumab,cetuximab,bevacizumab,apatinib,sorafenib sunitinib,lapatinib and everolimus which are targeting HER2,EGFR,VEGF and mTOR pathway,are applied in the comprehensive treatment of advanced gastric cancer,and their therapeutic effects are encouraging.
