Role of thyroid cancer-1 in tumorigenesis and progression
10.3760/cma.j.issn.1673-422X.2012.02.001
- VernacularTitle:TC-1蛋白表达在肿瘤发生发展中的作用
- Author:
Qiyao ZHANG
;
Hongtao XU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Genes;
Signal transduction;
TC-1
- From:
Journal of International Oncology
2012;39(2):83-85
- CountryChina
- Language:Chinese
-
Abstract:
thyroid cancer(TC-1 ),a nuclear protein coded by TC-1,regulates the cell cycle,participates transcription and translation,and is correlated with the proliferation of normal and cancer cells.TC-1 participates in the Wnt/beta-catenin signaling pathway which can promote the up-regulation of proto-oncogene.Hence it plays an important role in the malignant transformation and development of the tumors,such as thyroid cancer,gastric cancer and breast cancer.Therefore,as a potential tumor-associated protein,it's likely to be used for fundamental research and gene targeting therapy.
