Transcription factor Yin-Yang1 and tumor
10.3760/cma.j.issn.1673-422X.2012.02.003
- VernacularTitle:转录因子Yin-Yang1与肿瘤
- Author:
Yun TANG
;
Xueli LI
;
Xuezhu XU
- Publication Type:Journal Article
- Keywords:
Gene expression regulation;
Neoplasms;
YY1 transcription factor
- From:
Journal of International Oncology
2012;39(2):89-92
- CountryChina
- Language:Chinese
-
Abstract:
Yin-Yang1 (YY1),as a ubiquitous nuclear transcription factor with double transcriptional activity in eukaryotic cells,regulates many genes transcription and plays an important role in the cellule biological processes.Overexpression of YY1 is found in several tumor types recently,and may play a role in tumor development and progression by regulating oncogenes,tumor suppressor genes,angiogenesis related factors,as well as apoptosis.YY1 may become a new kind of tumor markers,is conducive to estimate the prognosis of patients with tumor and gain important breakthrough in cancer targeted therapy.
