Detection of epithelial neutrophil-activing peptide-78 and VE-cadherin in pregnant patients with obstructive sleep apnea hypopnea syndrome
10.3760/cma.j.issn.1008-6315.2012.02.005
- VernacularTitle:妊娠合并阻塞性睡眠呼吸暂停低通气综合征患者血清中性粒细胞激活肽-78和血管内皮细胞钙黏蛋白浓度的变化及意义
- Author:
Tong SU
;
Youmin HUANG
;
Yongqin ZHOU
- Publication Type:Journal Article
- Keywords:
Pregnancy;
Epithelial neutrophil-activing peptide-78;
Sleep apnea syndromes;
VE-cadherin hypopnea
- From:
Clinical Medicine of China
2012;28(2):124-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possible correlation between obstructive sleep apnea hypopnea syndrome(OSAHS)and serum epithelial neutrophil-activing peptide-78(ENA-78)and VE-cadherin in pregnant patients.Methods One hundred and two pregnant women combined with OSAHS,42 of which were with hypertension,and 36 healthy pregnant women were underwent polysomnography(PSG),and their apnea hypopnea index(AHI)was recorded.Based on the apnea hypopnea index(AHI),they were divided into mild OSAHS group(36 patients),moderate OSAHS group(34 patients)and severe OSAHS group(32 patients)Serum ENA-78 and VE-cadhefin levels were detected by enzyme-linked immunosorbent assay(ELISA),and mean arterial pressure(MAP)was measured simultaneously.Results The values of AHI,MAP,ENA-78 and VE-cadherin in OSAHS with hypertension were significantly higher than those of OSAHS only group(t =13.46,11.65,12.47,13.36,all P ＜ 0.01)and the control group(t =16.72,15.31,16.35,16.73,all P ＜ 0.01).The levels of serum ENA-78 and VE-cadherin were gradually significantly decreased in the order of severe OSAHS group,moderate OSAHS group and mild OSAHS group(P ＜0.01).The AHI of OSAHS group was significantly correlated with MAP,VE-cadherin,ENA-78(r =0.75,0.71,0.68,all P ＜ 0.01).ENA-78 of OSAHS group were positively correlated with MAP and VE-cadherin(r =0.64,0.67,all P ＜ 0.01).Conclusions The condition OSAHS in pregnant patients is closely related to the levels of ENA-78 and VE-cadherin.Pregnancy combined with OSAHS may take part in the pathological process of hypertensive disorder complicating pregnancy.
