The value of procalcitonin for the diagnosis of infection during the perioperative period of valve replacement for rheumatic heart disease
10.3760/cma.j.issn.1008-6315.2012.02.014
- VernacularTitle:血清降钙素原对风湿性心脏病围术期感染的诊断价值
- Author:
Yingjiu JIANG
;
Ning TANG
;
Qingcheng WU
;
Qiang LI
;
Cheng ZHANG
;
Lin YE
- Publication Type:Journal Article
- Keywords:
Procalcitonin;
Rheumatic heart disease;
Valve replacement;
Infections
- From:
Clinical Medicine of China
2012;28(2):149-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the variation of procalcitonin(PCT)level and the significance of PCT for the diagnosis of infection during perioperative period of valve replacement for rheumatic heart disease.Methods Routine blood testing and procalcitonin(PCT)level were measured in the perioperative period of 56 patients with rheumatic heart disease receiving valve replacement.Prophylactic antibiotics management was given based on the serum procalcitonin level especialy that 3 days after operation or later.The postoperative infective complications and the duration of prophylactic antibiotics management were recorded and assessed.Results The duration of prophylactic antibiotics for all patients were 4.6 ± 2.0 days.Six patients were suffered from poor incision healing and one was suffered from pulmonary infection.There were no severe postoperative infective complications.The PCT of the patients without postoperative infection rise to peak level on the 1st day after operation and return to normal on the 3rd day.There was no significant difference in the PCT levels between the two groups.The duration for PCT descending to 0.25 mg/L was 3.7 ± 2.5 days.The PCT level of the patients suffered from pulmonary infection went up again after infection on the 5th day and return to normal on the 9th day.No severe postoperative infective complications happened after withdrawn of prophylactic antibiotics if PCT had descended tobelow 0.25 mg/L after operation.Conclusions The serum PCT level may be a good parameter for the prediction or diagnosis of infective complication in the perioperative period of patients undergoing valve replacement for rheumatic heart disease.It can be a useful marker to guide the use of prophylactic antibiotics.
