A candidate tumor suppressor gene RIZ1
10.3760/cma.j.issn.1673-422X.2012.01.001
- VernacularTitle:候选抑癌基因RIZ1
- Author:
Xiaojian ZHU
;
Qiubai LI
;
Ping ZOU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Genes,tumor suppressor;
Methylation
- From:
Journal of International Oncology
2012;39(1):3-6
- CountryChina
- Language:Chinese
-
Abstract:
The retinoblastoma-protein-interacting zinc finger proteinl (RIZ1),a methyltransferase,contains the characteristic PR zinc finger domain.RIZ1 can methylate H3K9 of the histone,acted as a transcription suppression factor of cancers.Increasing numbers of human cancers are reported to hold decreased or absent RIZ1 expression,which is closely related to the progression of cancer.RIZ1 is defined as a candidate anti-oncogene.The mechanisms of the suppression involved in both oncocytogenetics and epigenetic changes.
