Composition, function in PI3K/Akt and PTEN, and the relationship with developing brain after hypoxiaischemia
10.3760/cma.j.issn.1673-4408.2012.01.006
- VernacularTitle:PI3K/Akt信号通路及PTEN与缺氧缺血性脑损伤
- Author:
Dan YAO
- Publication Type:Journal Article
- Keywords:
PI3 K/Akt;
PTEN;
Brain;
Hypoxia-ischemia
- From:
International Journal of Pediatrics
2012;39(1):20-22
- CountryChina
- Language:Chinese
-
Abstract:
P13K/Akt signaling pathway is an classic anti-apoptotic,urge-survival signal transduction pathway.It plays important regulation and control roles in neurons apoptosis.PTEN ( phosphatase and tensin homolog deleted on chromosome 10) is a highly conservative tumor suppressor gene with a dual-specificity phosphatase activity.PTEN protein can specifically dephosphorylats the 3 position of phosphoinositides,antagonize the PI3K/Akt signaling pathway,as negativity regulation and control roles to cell survival and growth.This review summarizes the progresses of the composition,function in PI3 K/Akt and PTEN,and the relationship with developing brain after hypoxia-ischemia.
