Anti-tumor Activity of Saussurea laniceps against Pancreas Adenocarcinoma.
10.20307/nps.2017.23.4.281
- Author:
Keyong Ho LEE
1
;
Byeong Soo KIM
;
Ki Hyeong RHEE
Author Information
1. Keyong Ho Lee, Across, Chuncheon 24398, Korea.
- Publication Type:Original Article
- Keywords:
Saussurea laniceps;
Pancreatic carcinoma;
Hispidulin;
Hollow fiber assay
- MeSH:
Adenocarcinoma*;
Cell Death;
Cell Line;
DNA Fragmentation;
Ethanol;
Humans;
Pancreas*;
Saussurea*
- From:Natural Product Sciences
2017;23(4):281-285
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to confirm the anti-tumor activity of an ethanol extract of Saussurea laniceps against pancreatic tumor and to isolate the active compound from S.laniceps extract. Treatment with S.laniceps extract and hispidulin inhibited proliferation of pancreatic cell lines, such as Capan-1, Capan-2, Panc-1 and S2-013 in a dose-dependent manner using the hollow fiber assay. Hispidulin showed typical hallmarks of apoptotic cell death a significant anti-tumor activity on Capan-2 cells at a dose of 100 mg/kg and 200 mg/kg. S.laniceps has potential cytotoxic and apoptotic effects on human pancreatic carcinoma cells. Its mechanism of action might be associated with the apoptotic cell death through DNA fragmentation.
