Wnt signaling pathway and bronchopulmonary dysplasia
10.3760/cma.j.issn.1673-4408.2012.01.013
- VernacularTitle:Wnt信号通路与支气管肺发育不良
- Author:
Shaohua WANG
- Publication Type:Journal Article
- Keywords:
Wnt signaling pathway;
Lung development;
Inflammation;
Pulmonary fibrosis;
Bronchopulmonary dysplasia
- From:
International Journal of Pediatrics
2012;39(1):43-45
- CountryChina
- Language:Chinese
-
Abstract:
Wnt signaling pathway is an conserved signaling pathway.Three signaling pathways are typically described for Wnt proteins:the canonical Wnt/β-catenin pathway,the noncanonical pathways including the polar cell polarity pathway and the Wnt/Ca2+ pathway.The complex components have diverse roles in regulating lung development and lung diseases.Bronchopulmonary dysplasia(BPD) is one of chronic lung diseases based on the immature lung due to inflammation damage and abnormal repair of pulmonary fibrosis after injury.This paper reviewed the roles of Wnt pathway in lung development,inflammation and pulmonary fibrosis in hope of revealing potential links between Wnt pathway and BPD.
