mTOR signaling pathway and colorectal cancer
10.3760/cma.j.issn.1673-422X.2012.01.018
- VernacularTitle:哺乳动物雷帕霉素靶蛋白信号通路与大肠癌
- Author:
Hui MA
;
Yanqing LIU
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
mTOR signaling pathway;
mTOR inhibitor
- From:
Journal of International Oncology
2012;39(1):57-60
- CountryChina
- Language:Chinese
-
Abstract:
Mammalian target of rapamycin (mTOR) signaling pathway,one of the most important cellular signaling transduction pathways,regulates cell survival,proliferation,transdifferentiation,migration and cell cycle by influencing the activation state of various effector molecules in the downstream.Abnormal regulations of these machanisms are closely related to the tumorigenesis and progression of colorectal cancer (CRC).Currently,mTOR inhibitors have been approved in clinical trials of CRC and have made some progress.
