Serum microRNA:a new class of biomarkers and targets of therapy
10.3760/cma.j.issn.1673-4408.2012.01.014
- VernacularTitle:血清微小RNA:一种新型生物标志物和治疗靶点
- Author:
Xiaoyi CAI
- Publication Type:Journal Article
- Keywords:
Serum microRNA;
Cellular microRNA;
Renal microRNA
- From:
International Journal of Pediatrics
2012;39(1):46-49
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA) are a class of small,non-coding,measuring 21-25 nucleotides in length RNA,which regulates protein levels post-transcriptionally through binding to 3'-untranslated region of target mRNA.miRNA involves in many physiological and pathological processes.Studies demonstrate that miRNA presents not only intracellular,but also in circulation and body fluids,e.g.urine,tear,ascetic fluid,and amniotic fluid,and these miRNA have become a novel biomarker and potential target of treatment,especially the serum miRNA.This review summarizes the recent advances of serum miRNA.
