Anti-inflammatory and Anti-bacterial Effects of Aloe vera MAP against Multidrug-resistant Bacteria.
10.20307/nps.2017.23.4.286
- Author:
Sang Hwa CHOI
1
;
Hea Soon SHIN
Author Information
1. College of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea. hsshin@duksung.ac.kr
- Publication Type:Original Article
- Keywords:
Aloe vera MAP;
Multidrug-resistant bacteria;
Anti-inflammatory;
Anti-bacterial effect
- MeSH:
Acinetobacter baumannii;
Aloe*;
Anti-Bacterial Agents;
Bacillus subtilis;
Bacteria*;
Diffusion;
Enterobacter aerogenes;
Escherichia coli;
Gram-Negative Bacteria;
Mass Screening;
Pressure Ulcer;
Pseudomonas aeruginosa;
Rivers;
Sepsis;
Skin;
Staphylococcus aureus;
Wound Infection
- From:Natural Product Sciences
2017;23(4):286-290
- CountryRepublic of Korea
- Language:English
-
Abstract:
Multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa are highly dangerous nosocomial pathogens, cause the symptoms of skin infections, pressure sores, sepsis, blood stream and wound infections. Unfortunately, these pathogens are immune to the most common antibiotics, such as, carbapenem, aminoglycoside and fluoroquinolone. Therefore, it is imperative that new and effective antibiotics be developed. In the present study, the antimicrobial effects of Aloe vera MAP (modified Aloe polysaccharide) on Staphylococcus aureus and Bacillus subtilis, Escherichia coli and Enterobacter aerogenes, and clinical Pseudomonas aeruginosa and clinical Acinetobacter baumannii were comprehensibly investigated. Prior to the growth inhibition effect measurement and antibiotic disc diffusion assay on gram-positive and gram-negative bacteria and selected multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii, antimicrobial resistance screening was performed for the multidrug-resistant bacteria obtained from clinical isolates. The results for showed the Aloe vera MAP had a concentration-dependent effect on all of examined bacteria, particularly on Pseudomonas aeruginosa. Anti-inflammatory and anti-oxidant experiments were also performed dose dependently effects to confirm the beneficial physiological effects of Aloe vera MAP.
