Progress of Notch gene's effect on children with acute leukemia
10.3760/cma.j.issn.1673-4408.2012.01.023
- VernacularTitle:Notch基因在儿童急性白血病中的作用及机制
- Author:
Xiaoli ZHAO
- Publication Type:Journal Article
- Keywords:
Notch;
Signaling pathway;
Leukemia;
Children
- From:
International Journal of Pediatrics
2012;39(1):79-82
- CountryChina
- Language:Chinese
-
Abstract:
The Notch receptors of mammalian include four kinds from Notch1 to Notch4.Notch ligands are divided into two families,Delta and Jagged,including Delta 1,Delta 3,Delta 4,Jaggedl and Jagged2.Notch signaling pathway is a complex network structure which is composed by receptors,ligands and downstream target genes,and it is closely related to cell proliferation,diferentiation and apoptosis.It has carcinoma suppressing or carcinogenic effects in different tissues and cells.This article mainly describes the regulation of Notch signaling pathway and its effect on children with acute leukemia.
