Cytotoxicity and Structure Activity Relationship of Dammarane-Type Triterpenoids from the Bark of Aglaia elliptica against P-388 Murine Leukemia Cells.
10.20307/nps.2017.23.4.291
- Author:
Ace Tatang HIDAYAT
1
;
Kindi FARABI
;
Desi HARNETI
;
Rani MAHARANI
;
DARWATI
;
NURLELASARI
;
Tri MAYANTI
;
Arlette Suzy SETIAWAN
;
Unang SUPRATMAN
;
Yoshihito SHIONO
Author Information
1. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia. unang.supratman@unpad.ac.id
- Publication Type:Original Article
- Keywords:
Dammarane-type Triterpenoids;
Aglaia elliptica;
Meliaceae;
P-388 murine leukimia cell
- MeSH:
Aglaia*;
In Vitro Techniques;
Leukemia*;
Meliaceae;
Methanol;
Plants;
Structure-Activity Relationship*
- From:Natural Product Sciences
2017;23(4):291-298
- CountryRepublic of Korea
- Language:English
-
Abstract:
Six dammarane-type triterpenoids, dammar-24-en-3β-ol (1), 3β-epicabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-3β,20-diol (3), dammar-24-en-3β,20-diol (4), 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (5), and 3β-epiocotillol (6) were isolated from the methanolic extract of the bark of Aglaia elliptica. The chemical structure were identified on the basis of spectroscopic evidence and by comparison with those spectra previously reported. Compounds 1 – 6 were isolated first time from this plant. Compounds 1 – 6, along with a known synthetic analog, cabraleone (7) were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (5) showed strongest cytotoxic activity with IC₅₀ value of 8.02 ± 0.06 µM.
