Advances on T helper 17 cells/regulatory T cells and leukemia

VernacularTitle:Th17细胞和调节性T细胞与白血病的研究进展
Author: Yanjun ZHANG
Publication Type:Journal Article
Keywords: T helper17 cell; Regulatory T cell; Leukemia
From: International Journal of Pediatrics 2012;39(1):88-91
CountryChina
Language:Chinese
Abstract: Thelper 17 ( Th17 ) cells and regulatory T (Treg) cells are resistant to each other in their functions and differentiation pathways.Th17 cells and Treg cells play different roles in the development,treatment and prognosis of leukemia.Their functions are stronger and(or) numbers are more increasing than in the healthy controls.Th17 cells mainly function to promote inflammation and improve the body's defense capability to leukemic cells.Treg cells mainly mediate immune suppression and immune tolerance,and then inhibit the body's immune response to leukemia cells,which can results in poor treatment outcomes.Both Th17 cells and Treg cells have close relationships with the development,treatment and prognosis of leukemia.We would deal with the leukemia through the intervention of naive T cell differentiation.