The diseases associated with costimulatory molecules B7 and cytotoxic T lymphocyte antigen-4
10.3760/cma.j.issn.1673-4408.2012.01.028
- VernacularTitle:协同刺激分子B7和细胞毒T细胞抗原-4与临床疾病
- Author:
Hui GUAN
- Publication Type:Journal Article
- Keywords:
B7;
Cytotoxic T lymphocyte antigen-4;
Disease
- From:
International Journal of Pediatrics
2012;39(1):96-99
- CountryChina
- Language:Chinese
-
Abstract:
Tcells need two signals to promote their activation.Only two signals existing at the same time,T cells can effectively activate,proliferate and secrete cell factors or play the toxic effects of cells.One signal is that T cell receptor recognize antigen and CD3 will transduce it to cells.The other is the combination of costimulatory molecules from antigen-presenting cell and costimulatory molecules receptor on the T cell surface.B7 on antigen-presenting cell and CD28/cytotoxic T lymphocyte-antigen-4 expressed on T cells are the most important costimulatory molecules.
