The 20 ％ magnesium sulfate for the treatment of the adult severe tetanus
10.3760/cma.j.issn.1673-4203.2012.01.005
- VernacularTitle:20％的硫酸镁在成人重症破伤风中的治疗作用
- Author:
Gang WEI
;
Xi ZHANG
;
Bixiang ZHANG
;
Wen LIU
;
Xiaoping CHEN
;
Yingtian ZHANG
- Publication Type:Journal Article
- Keywords:
Magnesium sulfate;
Severe tetanus;
Treatment
- From:
International Journal of Surgery
2012;39(1):11-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy and safety magnesium sulfate for the treatment of adult severe tetanus.MethodsTwenty-seven inpatients with adult severe tetanus during April 2005 - October 2010 were retrospectively analysed.ResultsThe total serum magnesium more than 4 mmol/L was found in 2 patients ( 2/27,7.40％ ).The tracheotomy was performed in 25 Patients (25/27,92.6％),22 of which (22/25,88.0％) run mechanical ventilation with the mean mechanical ventilation time (7.5 ± 3.7 ) days,(4 to 16 days).Pulmonary infection occurred in 25 cases (25/27,92.6％).Twenty-three of 27 (23/27,85.2％ ) cases were cured except 4 cases died,and the mean hospital stay was (32.22 ± 18.78) days,(25to 48) days.Conclusions20％ magnesium sulfate is safe for treatment of the patients of adult severe tetanus.It can control not only muscle rigidity and spasms but also autonomic instability efficaciously,and lower the dosage of sedative such as diazepam and chlorpromazine.This method is worth popularizing in clinical practice for its easy operation and low cost.
