Protective Effects of Cinnamic Acid Derivatives on Gastric Lesion.
10.20307/nps.2017.23.4.299
- Author:
Sun Yi LEE
1
;
In Young HWANG
;
Choon Sik JEONG
Author Information
1. College of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea. choonsik@duksung.ac.kr
- Publication Type:Original Article
- Keywords:
Cinnamic acid;
Gastritis;
Gastric acid;
H⁺/K⁺-ATPase
- MeSH:
Gastric Acid;
Gastric Emptying;
Gastritis;
Hand;
Models, Animal;
Molecular Weight;
Plants, Medicinal;
Polygala;
Proton Pumps
- From:Natural Product Sciences
2017;23(4):299-305
- CountryRepublic of Korea
- Language:English
-
Abstract:
P-methoxycinnamic acid and 3,4,5-trimethoxycinnamic acid are the compounds found in Polygalae Radix, the root of Polygala tenuifolia Willdenow, and have been reported to have hepatoprotective and anti-neurodegenerative effects. On the other hand, there are no reports of their effects on gastric lesions. This study examined the inhibitory effects of cinnamic acids, including p-methoxycinnamic acid, 3,4,5-trimethoxycinnamic acid, and 8 compounds (cinnamic acid, 2-(trifluoromethyl) cinnamic acid, 3-(trifluoromethyl) cinnamic acid, trans-4-(trifluoromethyl) cinnamic acid, 4-(dimethylamino) cinnamic acid, 3,4-(methylenedioxy) cinnamic acid and 3,4-dihydroxycinnamic acid), which were selected based on their presence in medicinal herbs and molecular weight, against gastric lesions. Animal models were used to confirm the protective effects on acute gastritis caused by the administration of HCl/EtOH. Gastric acid inhibition was examined by an acid-neutralizing test and the proton pump (H⁺/K⁺-ATPase) inhibiting activity. In addition, antioxidant tests were performed and the gastric emptying rate was determined. The results showed that cinnamic acid, p-methoxycinnamic acid, and 3,4,5-trimethoxycinnamic acid had an inhibitory effect on gastric lesions.
