Effect of mild hypothermia on the MBP level in the CSF of TBI patients

VernacularTitle:亚低温对创伤性脑损伤患者脑脊液髓鞘基本蛋白的影响
Author: Jianren WANG ; Xian FU ; Jiandong WU ; Qihua XIAO ; Surong QIAN ; Chenqiu WANG
Publication Type:Journal Article
Keywords: Traumatic brain injury; Myelin basic Protein; Mild hypothermia; Cerebrospinal fluid
From: Clinical Medicine of China 2012;28(2):152-154
CountryChina
Language:Chinese
Abstract: Objective To study the effect of mild hypothermia on MBP level in the CSF of TBI patients.Methods We investigated 36 patients with severe traumatic brain injury and randomized them into two groups,mild hypothermia treatment group and normathermia treatment group.The MBP levels in CSF and ICP and GOS scores in different time-points were evaluated.Results There was no significant difference between the two groups in the MBP level on the 1st day after treatment(P ＞ 0.05).The MBP levels in mild hypothermia group decreased greater than that in the control group on the 7th and 14th day after treatment(P ＜ 0.05).ICP decreased more in mild hypothermia group than in the control group(P ＜ 0.05)on the 7th and 14th day after treatment.Moreover,patients in mild hypothermia treatment group have better outcome than those in the control group(P ＜ 0.05),but there was no significant difference in the death rate between the two groups.Conclusion Mild hypothermia may provide neuroprotection by reducing MBP degradation and stabilizing medullary sheath,thus improving the prognosis of TBI patients.